2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-164815
    S 8849-1 free base
    S 8849-1 (free base) (Tianeptine metabolite MC5) is a Tianeptine (HY-90003) metabolite that is found in plasma. The mean elimination half-lives of S 8849-1 (free base) is 7.53 h in rats. S 8849-1 (free base) is promising for research of antidepressants.
    S 8849-1 free base
  • HY-137301R
    Mycophenolic acid glucuronide (Standard)
    Mycophenolic acid glucuronide (Standard) is the analytical standard of Mycophenolic acid glucuronide. This product is intended for research and analytical applications. Mycophenolic acid glucuronide is a metabolite of the immunosuppressant mycophenolic acid (MPA). Mycophenolic acid glucuronide shows anti-tumor activity and can be used in adenocarcinoma research.
    Mycophenolic acid glucuronide (Standard)
  • HY-N7857
    19(R)-Hydroxy-prostaglandin F2α
    19(R)-Hydroxy-prostaglandin F2α (19(R)-hydroxy PGF2α) is an ω-1 hydroxylase metabolite of PGF2α found in human semen. The concentration of 19(R)-Hydroxy-PGFs compounds (F2α and F1α together) in fresh human semen is about 20 μg/mL. 19(R)-Hydroxy-prostaglandin F2α exhibits no activity at the FP receptor of the cat iris sphincter muscle at concentrations up to 1 μM.
    19(R)-Hydroxy-prostaglandin F2α
  • HY-W045132S
    N-Desbutyl bupivacaine-d6
    N-Desbutyl bupivacaine-d6 (Desbutylbupivacaine-d6) is the deuterium labeled N-Desbutyl Bupivacaine (HY-W045132). N-Desbutyl Bupivacaine (compound 100) is a metabolite of Bupivacaine (HY-B0405), an NMDA receptor inhibitor and SCN5A antagonist.
    N-Desbutyl bupivacaine-d<sub>6</sub>
  • HY-144141S
    Nortriptyline impurity 3-d3 hydrochloride
    Nortriptyline impurity 3-d3 (hydrochloride) is the deuterium labeled Nortriptyline impurity 3 hydrochloride.
    Nortriptyline impurity 3-d<sub>3</sub> hydrochloride
  • HY-W759719
    21-Desacetyldeflazacort-d4
    21-Desacetyldeflazacort-d4 (21-desDFZ-d4) is the deuterium labeled 21-Desacetyldeflazacort (HY-100085). 21-Desacetyldeflazacort (21-desDFZ) is the active metabolite of Deflazacort (HY-13609). Deflazacort is an anti-inflammatory and immunosuppressant. Deflazacort is an inactive pro-drug which can be rapidly converted by esterases to the active metabolite 21-desacetyldeflazacort after oral administration.
    21-Desacetyldeflazacort-d<sub>4</sub>
  • HY-N3995S
    5β-Dihydrocortisol-d6
    5β-Dihydrocortisol-d6 is the deuterium labeled 5β-Dihydrocortisol. 5β-Dihydrocortisol, a metabolite of Cortisol, is a potential mineralocorticoid. 5β-Dihydrocortisol can potentiate glucocorticoid activity in raising the intraocular pressure. 5β-Dihydrocortisol causes breast cancer cell apoptosis.
    5β-Dihydrocortisol-d<sub>6</sub>
  • HY-147001
    5-O-Demethyl-28-hydroxy-Avermectin A1a
    5-O-Demethyl-28-hydroxy-Avermectin A1a is a degradation product of Avermectin B1a (HY-15308).
    5-O-Demethyl-28-hydroxy-Avermectin A1a
  • HY-143990S
    Modafinil EP impurity B-d5
    Modafinil EP impurity B-d5 is the deuterium labeled Modafinil EP impurity B.
    Modafinil EP impurity B-d<sub>5</sub>
  • HY-17026A
    Gemcitabine triphosphate
    Gemcitabine triphosphate (dFdCTP) is one of the two nucleoside metabolites of Gemcitabine (HY-17026) in cells. The other is active diphosphate (dFdDTP). Gemcitabine triphosphate can be used as a standard in radio-labeled probe imaging studies, to identify tumors sensitive to Gemcitabine, and to evaluate Gemcitabine uptake and retention by cells.
    Gemcitabine triphosphate
  • HY-17530S
    Aldicarb sulfone-13C2,d3
    Aldicarb sulfone-13C2,d3 is the deuterium and 13C labeled Aldicarb sulfone (HY-17530). Aldicarb sulfone is one of the metabolites of the carbamate pesticide Aldicarb and has insecticidal activity. Aldicarb sulfone is also an inhibitor of cholinesterase.
    Aldicarb sulfone-<sup>13</sup>C<sub>2</sub>,d<sub>3</sub>
  • HY-B2150S
    4-Hydroxyantipyrine-d3
    4-Hydroxyantipyrine-d3 is the deuterium labeled 4-Hydroxyantipyrine. 4-Hydroxyantipyrine is the major metabolite of Antipyrine, can be as a biodistribution promoter. 4-Hydroxyantipyrine can increase distribution of concentration ratio of Antipyrine in the brain.
    4-Hydroxyantipyrine-d<sub>3</sub>
  • HY-121208R
    Ketanserinol (Standard)
    Cycloate (Standard) is the analytical standard of Cycloate. This product is intended for research and analytical applications. Cycloate is an active compound.
    Ketanserinol (Standard)
  • HY-Z9063
    1-epi-Regadenoson
    1-epi-Regadenoson is an αisomer impurity of Regadenoson which is a highly selective adenosine A2A receptor agonist.
    1-epi-Regadenoson
  • HY-G0008
    O-Desmethyl Mebeverine alcohol
    O-Desmethyl Mebeverine alcohol is a metabolite of Mebeverine, which is a potent α1 repector inhibitor, causing relaxation of the gastrointestinal tract.
    O-Desmethyl Mebeverine alcohol
  • HY-143956S
    Fluorofenidone impurity 1-d3
    Fluorofenidone impurity 1-d3 is the deuterium labeled Fluorofenidone impurity 1.
    Fluorofenidone impurity 1-d<sub>3</sub>
  • HY-131251
    Cetirizine 3-chloro impurity
    Cetirizine 3-chloro impurity is an impurity of Cetirizine 3-chloro.
    Cetirizine 3-chloro impurity
  • HY-153043
    DM-CO-(CH2)5-SMe
    DM-CO-(CH2)5-SMe is an anticancer agent derived from antibody-drug conjugates (ADC) metabolite with cytotoxicity to H1703, H1975, COLO704 and Colo720E cells.
    DM-CO-(CH2)5-SMe
  • HY-101407R
    Nicotinamide N-oxide (Standard)
    Nicotinamide N-oxide (Standard) is the analytical standard of Nicotinamide N-oxide. This product is intended for research and analytical applications. Nicotinamide N-oxide, an in vivo nicotinamide metabolite, is a potent, and selective antagonist of the CXCR2 receptor.
    Nicotinamide N-oxide (Standard)
  • HY-112057
    Pseudoerythromycin A enol ether
    Pseudoerythromycin A enol ether (LY267108) is a degradation product of Erythromycin. Pseudoerythromycin A enol ether has no significant antimicrobial activity.
    Pseudoerythromycin A enol ether
Cat. No. Product Name / Synonyms Application Reactivity