2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-135000
    Decarbamoylsaxitoxin
    Decarbamoylsaxitoxin is an acid hydrolysis product of saxitoxin. Decarbamoylsaxitoxin is a potent neurotoxin that has a lower potency than saxitoxin .
    Decarbamoylsaxitoxin
  • HY-148375R
    Abiraterone sulfate (Standard)
    Bis(2-ethylhexyl) maleate (Standard) is the analytical standard of Bis(2-ethylhexyl) maleate. This product is intended for research and analytical applications. Bis(2-ethylhexyl) maleate can enhance the water sensitivity of polyvinyl acetate (PVAc) films and improve the tackiness, adhesion, and wash resistance of polyacrylate.
    Abiraterone sulfate (Standard)
  • HY-145000
    N-Desalkyludenafil
    N-Desalkyludenafil is a metabolite of Udenafil. Udenafil is a PDE5 inhibitor used for the research of the erectile dysfunction.
    N-Desalkyludenafil
  • HY-114750S
    Mebendazole-amine-13C6
    Mebendazole-amine-13C6 is the 13C6 labeled Mebendazole-amine. Mebendazole-amine is a metabolite of Mebendazole. Mebendazole is a broad-spectrum benzimidazole anti-helminthic agent.
    Mebendazole-amine-<sup>13</sup>C<sub>6</sub>
  • HY-70002BR
    Enzalutamide carboxylic acid (Standard)
    Bromoxynil octanoate (Standard) is the analytical standard of Bromoxynil octanoate. This product is intended for research and analytical applications. Bromoxynil octanoate is an herbicide widely applied to maize, is potentially toxic to both animals and humans.
    Enzalutamide carboxylic acid (Standard)
  • HY-167869
    A-849529
    A-849529 is an acid metabolite of ABT-869 (HY-50751). ABT-869 is a potent and orally active multi-target inhibitor of VEGFR and PDGFR family.
    A-849529
  • HY-137339
    Amitriptyline N-β-D-glucuronide
    Amitriptyline N-β-D-glucuronide is an ammonium glucuronide and an urinary excretion metabolite of amitriptyline.
    Amitriptyline N-β-D-glucuronide
  • HY-143986S1
    DM50 impurity 1-d9-1
    DM50 impurity 1-d9-1 is the deuterium labeled DM50 impurity 1.
    DM50 impurity 1-d<sub>9</sub>-1
  • HY-W748582
    Clozapine N-oxide-d8
    Clozapine N-oxide-d8 is the deuterium labeled Clozapine N-oxide (HY-17366). Clozapine N-oxide is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide can't cross the blood-brain barrier. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist.
    Clozapine N-oxide-d<sub>8</sub>
  • HY-G0018R
    Norgestimate metabolite Norelgestromin (Standard)
    Norgestimate metabolite Norelgestromin (Standard) is the analytical standard of Norgestimate metabolite Norelgestromin. This product is intended for research and analytical applications.
    Norgestimate metabolite Norelgestromin (Standard)
  • HY-141621
    ACT-606559
    ACT-606559, a new chemical entity with antimalarial activity, is a metabolite of ACT451840. ACT-606559 can be used for the research of malarial.
    ACT-606559
  • HY-132143A
    7-Deaza-7-propargylamino-dATP tetralithium
    7-Deaza-7-propargylamino-dATP tetralithium is an analog of deoxyadenosine triphosphate (dATP) that can be used for gene sequencing.
    7-Deaza-7-propargylamino-dATP tetralithium
  • HY-124087R
    (±)-2-Propyl-4-pentenoic acid (Standard)
    (±)-2-Propyl-4-pentenoic acid (Standard) is the analytical standard of (±)-2-Propyl-4-pentenoic acid. This product is intended for research and analytical applications. (±)-2-Propyl-4-pentenoic acid (4-en-VPA) is a major toxic metabolite of Valproic acid. (±)-2-Propyl-4-pentenoic acid exhibits neuroteratogenicity[1][2].
    (±)-2-Propyl-4-pentenoic acid (Standard)
  • HY-144142S
    Orphenadrine impurity 6-d3 hydrochloride
    Orphenadrine impurity 6-d3 (hydrochloride) is the deuterium labeled Orphenadrine impurity 6 hydrochloride.
    Orphenadrine impurity 6-d<sub>3</sub> hydrochloride
  • HY-137083A
    Trifluoperazine N-glucuronide chloride
    Trifluoperazine N-glucuronide (UGT1A4) chloride is a metabolite of the antipsychotic agent trifluoperazine. Trifluoperazine N-glucuronide (UGT1A4) chloridecatalyzes the imipramine and trifluoperazine Nglucuronide formation.
    Trifluoperazine N-glucuronide chloride
  • HY-131254
    (S)-O-Desmethyl Venlafaxine N-Oxide
    (S)-O-Desmethyl Venlafaxine N-Oxide is a N-oxyde of (S)-O-Desmethyl Venlafaxine. O-Desmethyl Venlafaxine is an active metabolite of Venlafaxine. Venlafaxine (HY-B0196) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.
    (S)-O-Desmethyl Venlafaxine N-Oxide
  • HY-W767767
    2-Oxo-3-hydroxy-LSD-d10
    2-Oxo-3-hydroxy-LSD-d10 is the deuterium labeled 2-Oxo-3-hydroxy-LSD (HY-137386). 2-Oxo-3-hydroxy-LSD is a metabolite of Lysergic acid diethylamide.
    2-Oxo-3-hydroxy-LSD-d<sub>10</sub>
  • HY-N15754
    3-Hydroxy-2-methylglutaric acid
    3-Hydroxy-2-methylglutaric acid is a carboxylic acid metabolite. 3-Hydroxy-2-methylglutaric acid can be isolated from the flower Veronica incana L. 3-Hydroxy-2-methylglutaric acid can be used for upper respiratory tract diseases, malignant neoplasms, gastrointestinal tract and genitourinary system disorders and diabetes mellitus research.
    3-Hydroxy-2-methylglutaric acid
  • HY-121432
    Kitol
    Kitol is peptide used for after-sun repair cosmetics. The dominant degradation reaction for vitamin A derivatives is heat-induced formation of kitols, i.e., dimers or higher oligomers. Vitamin A esters are used as a model system to evaluate microcalorimetry as a tool for monitoring the stability of heat-sensitive substances.
    Kitol
  • HY-I0736R
    Isonicotinic acid (Standard)
    Isonicotinic acid (Standard) is the analytical standard of Isonicotinic acid. This product is intended for research and analytical applications. Isonicotinic acid is a metabolite of Isoniazid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the Isoniazid to Isonicotinic acid biotransformation also to be catalyzed by cytochrome P450 (CYP) enzymes, e.g., CYP2C.
    Isonicotinic acid (Standard)
Cat. No. Product Name / Synonyms Application Reactivity